AIMP1/p43 negatively regulates adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma
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چکیده
منابع مشابه
AIMP1 negatively regulates adipogenesis by inhibiting PPARc
Adipogenesis is known to be controlled by the concerted actions of transcription factors and co-regulators. However, little is known about the mechanism of regulation of the transcription factors that control adipogenesis. In addition, the adipogenic roles of translational factors remain unclear. Here, we show that aminoacyl tRNA synthetaseinteracting multifunctional protein 1 (AIMP1, also know...
متن کاملAIMP1 negatively regulates adipogenesis by inhibiting PPARγ.
Adipogenesis is known to be controlled by the concerted actions of transcription factors and co-regulators. However, little is known about the mechanism of regulation of the transcription factors that control adipogenesis. In addition, the adipogenic roles of translational factors remain unclear. Here, we show that aminoacyl tRNA synthetase-interacting multifunctional protein 1 (AIMP1, also kno...
متن کاملPPARG ( peroxisome proliferator - activated receptor gamma )
Note: The PPAR gamma gene, a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear hormone receptors, is implicated in adipocyte differentiation and function. In order to regulate the transcription of target genes, the PPAR protein needs to form heterodimers with retinoid X receptors (RXRs). Three splice variants of PPAR gamma are known: PPAR gamma1, PPAR gamma2, ...
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Osteoarthritis (OA) is among the most prevalent chronic human health disorders and the most common form of arthritis. It is a leading cause of disability in developed countries. This disease is characterized by cartilage deterioration, synovitis, and remodeling of the subchondral bone. There is not yet a satisfactory treatment to stop or arrest this disease process. Although several candidates ...
متن کاملتعیین پلی‌مورفیسم ژن Peroxisome proliferator-activated receptor-gamma در بیماران مبتلا به عفونت با هلیکوباکتر پیلوری
سابقه و هدف: پروتئین (PPAR g ) Peroxisome proliferator-activated receptor-gamma یک فاکتور رونویسی وابسته به لیگاند است که در فرایند بیماری‌های مختلف از جمله فرایندهای التهابی و سرطان دخیل است. هدف از این پژوهش بررسی پلی‌مورفیسم ژن PPAR g و ارتباط آن با عفونت هلیکوباکتر پیلوری و بیماری‌های دستگاه گوارش در بیماران بود. مواد و روش ها: در این بررسی 200 بیمار مبتلا به هلیکوباکتر پیلوری وارد مط...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2014
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.154930